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Any information on long term effects of ttts would be great! Huskiemom4. One of my 26 year old ttts babies just recently started having heart issues. In the past 3 weeks she visited the er 3 times and was admitted once. Many of the symptoms of mild ttts, including anemia and polycythemia (a high red blood cell count), can be successfully treated after birth. Indomethacin is an aspirin-like medication (non-steroidal anti-inflammatory drug) with numerous side effects in the baby, one of which is on the kidney where decreased urine production occurs. It is the most powerful drug for treating pre-term labor and is used more often for this purpose in ttts. It can cause organ damage such as renal failure in the donor due to poor blood perfusion which causes damage of some of the more sensitive cells in the kidney (usually the tubular cells or nephrons), cardiac failure in the recipient from overwork of the heart, and also some risk of brain damage due to low oxygen related to anemia or due to clots. Posted in uncategorized, tagged long term effects of ttts, loss of twins, ttts, twin to twin transfusion syndrome, twins on august 10, 2012 leave a comment if you are wondering about any long term effects of twin to twin transfusion syndrome (ttts) google twin to twin transfusion syndrome long term effects. Twin to twin transfusion syndrome (ttts) is a serious disorder that occurs in identical twins and higher-order multiples who share a placenta. This occurs when the blood vessels of the babies shared placenta are connected. This results in one baby (this twin is referred to as the recipient) receiving more blood flow, while the other baby (this twin is referred to as the donor) receives too. Donofrio, in heart failure in the child and young adult, 2018. Ttts affects about 20 of the monochorionic twin pregnancies with an overall prevalence of 1310,000 pregnancies. The condition originates from an imbalance of placental flow due to abnormal placental vascular connections between the twins. Objective to estimate the odds of severe cerebral injury and long-term neurodevelopmental impairment in monochorionic twins treated with amnioreduction versus laser surgery for twin-twin transfusion syndrome. Database of abstracts of reviews of effects (dare) quality-assessed reviews internet - centre for reviews and dissemination (uk).